Human Cloning – Brain Ethics http://brainethics.org/ Mon, 21 Jun 2021 17:19:29 +0000 en-US hourly 1 https://wordpress.org/?v=5.7.2 https://brainethics.org/wp-content/uploads/2021/05/brain-ethics-icon-150x150.png Human Cloning – Brain Ethics http://brainethics.org/ 32 32 Conference of Catholic Democrats Bishops – OpEd – Eurasia Review https://brainethics.org/2021/06/21/conference-of-catholic-democrats-bishops-oped-eurasia-review/ https://brainethics.org/2021/06/21/conference-of-catholic-democrats-bishops-oped-eurasia-review/#respond Mon, 21 Jun 2021 16:20:15 +0000 https://brainethics.org/2021/06/21/conference-of-catholic-democrats-bishops-oped-eurasia-review/

Seems like everyone is lecturing bishops these days.

The latest to do so are 59 Democrats who identify as Catholics. At the head of the charge is the representative Rosa DeLauro. On June 18, she issued a “Declaration of Principles” which reprimands bishops for addressing the issue of Catholic public figures who reject basic Catholic moral teachings; 73% of bishops voted to consider a document on the suitability of these self-identified Catholics to receive Holy Communion.

DeLauro has a long history of telling bishops what to do.

In 2006, she published a “Declaration of Principles”, signed by 55 self-proclaimed Catholic Democrats, affirming that one can be a Catholic in good standing and promote the right to abortion. In 2007, she was one of 18 self-proclaimed Catholic Democrats to criticize Pope Benedict XVI on this subject. In 2015, she led a contingent of 93 self-identified Catholic Democrats explaining to Pope Francis the issues he had to solve when he came to the United States: The right to life was not one of them, but change. climate has made the difference.

In the latest “Declaration of Principles”, DeLauro and his company say they are proud to be part of the Catholic tradition which “expresses a coherent moral framework for life”, adding that they “agree with the Catholic Church on the value of human life. “Yet virtually all of the signatories have a pro-abortion vote record.

DeLauro voted for research on human embryonic stem cells, a process that involves the killing of nascent human life. It opposes human cloning for reproductive purposes against the law. She has consistently voted against banning partial birth abortions and achieved a 100% NARAL score on abortion legislation.

The “Declaration of Principles” expresses dismay at poverty, asserting that better “access to education for all” is needed. Still, DeLauro voted against having to work for able-bodied welfare recipients. In other words, it wants to keep the poor unemployed instead of allowing them to lift themselves out of poverty.
She also voted against every choice of school bills ever proposed, making it laughable for her to suggest that she wants “access to education for all”. In fact, she voted against reauthorizing the Washington DC scholarship program, the initiative that has worked so well for poor African Americans.

DeLauro and his self-identified Catholic Democrats made their biggest media noise saying how hypocritical it is for bishops to focus on abortion and not the death penalty, to which the Catholic Church s ‘opposite. Perhaps it is because they are not equal.

It is estimated that between 1973 and 2019, 61,628,584 innocent children were killed in their mother’s womb. The number of convicted felons who were executed during this period was 1,512.

Curiously, the “Declaration of Principles” encourages “alternatives to abortion”.

But why are alternatives needed if abortion doesn’t kill? Is there something lurking inside these self-identified pro-abortion Catholic Democrats that makes them think? We need to know what it is, because if they do understand that abortion kills innocent human lives, they would easily get away with it if the bishops simply refused them Communion.

Contact DeLauro’s chief of staff, Liz Albertine:[email protected]


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What are monoclonal antibodies and how important are they in the treatment of Covid-19? https://brainethics.org/2021/06/21/what-are-monoclonal-antibodies-and-how-important-are-they-in-the-treatment-of-covid-19/ https://brainethics.org/2021/06/21/what-are-monoclonal-antibodies-and-how-important-are-they-in-the-treatment-of-covid-19/#respond Mon, 21 Jun 2021 04:50:19 +0000 https://brainethics.org/2021/06/21/what-are-monoclonal-antibodies-and-how-important-are-they-in-the-treatment-of-covid-19/

An experimental cocktail of monoclonal antibodies, REGEN-COV2, has been shown to be a life-saving treatment for some of the most severely affected Covid-19 patients, the results of a clinical trial in the United Kingdom have shown. How important are the results for the management of Covid-19, including in India?

What are monoclonal antibodies?

To fight a viral infection, our body creates proteins called antibodies. Monoclonal antibodies are artificial antibodies that mimic the activity of our immune system. They are produced by a process of extracting specific antibodies from human blood and then cloning them.

These monoclonal antibodies are designed to target a virus or a specific part of a virus – for example, REGEN-COV2 is a cocktail of two monoclonal antibodies developed to target the SARS-CoV-2 spike protein. Monoclonal antibodies bind to specific parts of the spike protein, blocking its ability to infect healthy cells.

In addition to Covid-19, monoclonal antibodies have been used in the treatment of cancers as well as Ebola and HIV.

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What is their importance in the treatment of Covid-19?

Research during the pandemic has heightened optimism about the ability of monoclonal antibodies to help reduce the risk of hospitalization. Some monoclonal antibodies have been shown to be able to retain activity against several variants of the virus, suggested Dr.Anthony Fauci, chief medical adviser to the US president and director of the US National Institute of Allergy and Infectious Diseases, at a briefing at the White House on June 3. .

Although they are a crucial and promising part of treatment, monoclonal antibodies also have limitations. So far, these therapies have been most successful in high-risk groups with mild to moderate Covid-19. They are not approved for use in people hospitalized with severe Covid-19 and those requiring oxygen.

Delivering them to the “right patients at the right time” is very important for the greatest benefits, especially in resource-constrained environments, according to Dr D Behera, Padma Shri and former division head of PGIMER’s Respiratory Department. Chandigarh.

Some emerging variants like the ‘variant of interest’ Delta Plus have also shown the ability to override the use of monoclonal antibodies, according to Dr. VK Paul, NITI Aayog health member and chair of the National Expert Panel. on the administration of vaccines against Covid-19.

What does the new study show?

The University of Oxford said last week that its RECOVERY trials found that for hospitalized patients with severe Covid-19 “who have not developed their own natural immune response,” the cocktail of monoclonal antibodies from Regeneron reduced the risk of death by a fifth compared to those who had received standard care. “So for 100 of those patients treated with the combination of antibodies, there would be six fewer deaths,” the university said in a statement.

The therapy reduced hospital stays by four days for patients lacking their own natural immune response. It also reduced their risk of needing a ventilator. However, “no such benefit was observed in the overall study population”, which includes patients who may have developed a natural antibody response.

These results essentially mean that the therapy would be more beneficial for those who have not been able to develop their own antibody response, even if they have developed severe symptoms or have been hospitalized.

With 9,785 participants between September 2020 and May 2021, this is the first trial large enough to determine “definitively” whether this treatment reduces mortality in hospitalized patients with severe Covid-19. This is important, given that this therapy has so far only been approved for mild to moderate Covid patients.

Is this therapy available in India?

REGEN-COV2 is available in India thanks to a partnership between the Swiss pharmaceutical giant Roche and the Indian company Cipla. The therapy, a combination of monoclonal antibodies casirivimab and imdevimab, had received restricted emergency use approval from the Central Drugs Standard Control Organization in May.

In early June, another antibody cocktail therapy – Eli Lilly’s bamlanivimab and etesevimab – received similar emergency approval.

Both cocktails of antibodies are indicated for use in people with mild to moderate Covid-19 who do not need oxygen and are at high risk of progressing to serious illness.

GlaxoSmithKline, which on May 26 announced the US FDA’s emergency use approval for Sotrivimab, is exploring options to make monoclonal antibody therapy available for India.

In India, Zydus Cadila plans to take an antibody cocktail, ZRC-3308, in trials.

Is it expensive?

Such therapies are expensive because they are difficult to perform and take a long time. In India, Cipla supplies 100,000 packs of REGEN-COV2 at a maximum retail price of around Rs 1.20 lakh per pack. With a pack offering a treatment for two patients, the price of a dose for one patient is Rs 59,750, all taxes included.

Eli Lilly is engaged in an “active dialogue” with the Indian government to “donate” his cocktail of antibodies to Covid-19 patients.

Monoclonal antibodies must be made in tissue culture, said Dr Arturo Casadevall, chair of the Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health. “You have to grow the cells. And those cells have to produce the protein which then has to be purified, ”Dr Casadevall said in the school’s“ Public Health on Call ”podcast on Nov. 2.

How do monoclonal antibodies compare to convalescent plasma therapy?
Last month, India abandoned the use of convalescent plasma as an ‘off-label’ option from its Covid-19 treatment guidelines. Over the past eight months, evidence from trials has shown that it does not have significant benefits in improving patient outcomes.

Compared to plasma, scientists have expressed more confidence in the promise of monoclonal antibodies. The two antibody therapies, they differ in the way they are made.

Convalescent plasma therapy involves delivering antibodies from plasma recovered from a Covid-19 patient. This means that those who receive this therapy will get all the antibodies that the recovered patient has made.

Monoclonal antibodies are the process of taking a specific antibody and mass-producing it in a factory. For antibody cocktails, you provide a combination of two or more of these antibodies.

Monoclonal antibodies are “extremely pure” due to their homogeneous nature, Dr. Fauci told MedPage Today in August. “The difference between monoclonal antibodies and convalescent plasma is (that) the plasma contains a lot of other things, which could lead to allergic and other reactions,” Fauci said. Data from clinical trials of monoclonal antibodies at the time indicated that it was a “very promising form of prevention and treatment,” Dr Fauci said.


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X-Men: X-Corp Reveals They Are Potential New Board Members https://brainethics.org/2021/06/19/x-men-x-corp-reveals-they-are-potential-new-board-members/ https://brainethics.org/2021/06/19/x-men-x-corp-reveals-they-are-potential-new-board-members/#respond Sat, 19 Jun 2021 03:35:45 +0000 https://brainethics.org/2021/06/19/x-men-x-corp-reveals-they-are-potential-new-board-members/

At the height of the Hellfire Gala, the X-Corp is considering a number of candidates for the board of directors of the mutant company.

WARNING: The following contains spoilers for Tini Howard, Alberto Foche, Clayton Cowles of Sunny Gho, and VC’s X-Corp # 2, on sale now.

X-Corp is expected to be a major force for Krakoa in the near future, with the company bringing large companies to Krakoa. However, as they establish themselves in the world, they need to expand their board of directors to include more notable faces.

During the Hellfire gala, Angel and Penenance turned out to have met some of the top candidates for the job, and even gave one of the candidates a major role within the company.

RELATED: X-Men: Professor X Was Marvel’s Ultimate Secret Powerhouse

SOLAR HEAD

Sunspot X-Corp Hellfire Gala X-Men

Sunspot is one of the original New Mutants who has grown into one of the most tax-powerful mutants in the universe. Since Krakoa’s formation, he has gained more wealth living in Shi’Ar space, finding a way to improve relations between Krakoa and this intergalactic empire. It also turns out that Sunspot is a major investor in X-Corp and has given them a lot of the resources they use. Sunspot wants a seat on the board to reflect its contributions, promising to provide even more resources to the group. But it remains to be seen if that will earn him more power in the company.

Selene

Selene X-Men X-corp Hellfire Gala

Selene is one of the Externs, a near-immortal figure who has lived for thousands of years. She spent much of that time as an established enemy of the X-Men and their allies, but apparently made peace with them when she came to Krakoa – though her activities outside the island have been monstrous in itself. She presents herself as an authoritative voice to add to the board – someone with ideas that Monet finds interesting. However, Angel seems more uncomfortable with the prospect, which makes her less likely to win a position within the company’s leadership.

RELATED: Scarlet Witch and Quicksilver Became Complete Lannister in Marvel’s Ultimate Universe

BISHOP

The Time-Displaced Mutant Bishop is a longtime ally of the X-Men and has played a number of important roles in Krakoa. He was a member of the Marauders and is one of the great captains of Krakoa, making him one of the main military leaders of the mutant nation. As a result, he’s been stretched enough already, and it’s understandable that when X-Corp approached him about possibly joining the board, he politely declined. However, he had a candidate in mind to replace him.

thunder bird

X-Corp X-Men Thunderbird

Neal Shaara – aka Thunderbird – was a prominent member of the X-Treme X-Men. Though he’s been a rather underused figure in the mutant world, Thunderbird has been a steadfast ally of the X-Men over the years, earning him recommendations from Bishop and Sunspot. Due to its energy manipulation capabilities, it is necessary for an undisclosed plan by the business. In return, Thunderbird wants representation at the enterprise level. Turns out he’s even helped X-Corp before – meaning that even if he doesn’t end up on the board, it’s likely the group will continue to use his abilities.

RELATED: Marvel’s Hellfire Gala Reveals Which X-Men The New Mutants Voted For

RISK

Gloria Muñoz was an X-Force member who was able to create localized gravity fields, allowing her to compress objects into smaller objects without losing their density. She was killed years ago and is one of many mutants resurrected in Krakoa – becoming a member of SWORD’s Six and offering another major step forward for mutant abilities. It appears that Monet and Angel considered her a possible candidate for the leadership of X-Corp, but the Wind Dancer report suggests that Risque had little interest in joining the organization and did not respond to their outreach.

SARA ST. JOHN

X-Corp X-Men St. Scott Hellfire Gala

Sara St. John stands out from the rest of the potential candidates for business with X-Corp as she is the only person currently being considered for a position there. A genius inventor that both Angel and Monet have concerns about, Sara is at the Hellfire Gala as a guest when she has a reunion scheduled with the couple. However, his willingness to do business with the Fenris Twins soured the heads of X-Corp on St. John, who seems rather content to work with the disgraced Upstarts.

BRAIN

Mastermind is a former X-Men villain and master illusionist whose ability to control the perceptions of others has made him a serious threat in the past. However, since his resurrection in Krakoa, Mastermind has moved widely behind the scenes – working with Mister Sinister and even briefly defeating the Hellions on a mission to give Sinister his own private cloning lab. Ultimately, Mastermind actually impresses the pair throughout X-Corp # 2 and win one of the posts.

KEEP READING: X-Men’s Hellfire Gala Teases Emma Frost’s Connection to a Major Marauders Enemy

X-Corp Hellfire Gala

X-Men: A Hellfire Villain Just Gained A VITAL Leadership Role


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Heroic Pig Who Survived 2008 Sichuan Earthquake Dies Aged 14; What makes this animal special? https://brainethics.org/2021/06/18/heroic-pig-who-survived-2008-sichuan-earthquake-dies-aged-14-what-makes-this-animal-special/ https://brainethics.org/2021/06/18/heroic-pig-who-survived-2008-sichuan-earthquake-dies-aged-14-what-makes-this-animal-special/#respond Fri, 18 Jun 2021 12:00:40 +0000 https://brainethics.org/2021/06/18/heroic-pig-who-survived-2008-sichuan-earthquake-dies-aged-14-what-makes-this-animal-special/

A pig that rose to prominence in China after spending 36 days under the rubble in a severe earthquake in 2008 has died.

According to the museum of the Chinese region of Sichuan where the animal resided, Zhu Jianqiang, or “pig with a strong will”, died Wednesday evening of “old age and exhaustion”.

He was seen as a symbol of optimism and resilience at the time of his rescue.

(Photo: Scott Olson / Getty Images)
[REPRESENTATIONAL PHOTO] ELMA, IA – APRIL 28: Pigs are raised at Gordon and Jeanine Lockie’s farm on April 28, 2009, in Elma, Iowa. Pig farmers who have been battered by rising feed prices now face falling pork prices due in part to misconceptions about the relationship between swine flu and pork consumption and recent bans import raw American pork from certain countries.

Millions of people have paid tribute to the pig’s long life on Chinese social media site Weibo.

Zhu Jianqiang died at the age of 14, according to the Sichuan Museum in Jianchuan.

What happened in Sichuan in 2008?

A resident of Tuanshan Village in Chengdu, Sichuan Province, owned the female pig. After the 7.9 magnitude earthquake in May 2008, Zhu Jiangqiang was trapped under a full load of charcoal and rainwater and survived for 36 days. Apple Daily says the pig’s weight dropped from 150 kg (330.7 lbs) to 50 kg (110.2 lbs).

According to rescuers, by the time it was released, the pig was so thin it looked like a goat. It is claimed that he was severely traumatized as a result of being trapped.

It was purchased by a museum in Chengdu for 3,008 yuan ($ 450) and touted as a tourist attraction. The museum warned earlier this year that the animal would not be around for very long.

Scientists have made a Zhu Jianqiang clone

Scientists cloned the pig in 2011, producing six piglets that looked identical to their father, except for a spot between their eyes.

Although Zhu was neutered and aged five (60 human years) at the time, the cloning attempt was successful.

READ ALSO : Fragile stars with thousands of “pig muzzles” and a nest of thorny teeth found

“The wonderful pig surprised us again,” Du Yutao, head of the cloning project, told the Sunday Morning Post (via BBC).

South China Morning Post said the project spent a hefty price of 10,000 yuan (about $ 1552) for each piglet due to their father’s “heroic” genes. Doctors at a Shenzhen biotech company deliberately altered their genes so that they weren’t similar.

What made the pig special

The Sichuan Jianchuan Museum said that many tourists have visited Zhu every day.

What lies behind the attention is not just a pig, but a collective memory, the museum explained on Chinese social media platform Weibo.

“It’s a miracle of life; it’s a symbol of strong will,” the museum said (via The New York Post).

The rescue gripped the nation to the point where Jianchuan Museum owner Fan Jianchuan bought the pig so that Zhu could be called back every day.

Fan bought the pig to prevent it from being slaughtered. The owner of the museum never expected Zhu to live any longer. However, the health of the pig deteriorated over time.

China mourns the death of a pig

People have flocked to social media after hearing about the pig’s death to express their condolences. The hashtag “Strong-Willed Pig is dead” has received at least 430 million views on Weibo.

“Thank you for interpreting the greatness of life with your own strength,” one user said by BBC.

“RIP, you are the miracle of life and the symbol of strength,” wrote another.

RELATED ARTICLE: COVID-19 pandemic leads to increase in animal abuse and abandonment: here’s why

Discover more news and information about Animals in Science Times.


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What job title would you like engraved on your gravestone? “Beloved father, slayer of dragons, register of estates” • The register https://brainethics.org/2021/06/18/what-job-title-would-you-like-engraved-on-your-gravestone-beloved-father-slayer-of-dragons-register-of-estates-the-register/ https://brainethics.org/2021/06/18/what-job-title-would-you-like-engraved-on-your-gravestone-beloved-father-slayer-of-dragons-register-of-estates-the-register/#respond Fri, 18 Jun 2021 08:30:00 +0000 https://brainethics.org/2021/06/18/what-job-title-would-you-like-engraved-on-your-gravestone-beloved-father-slayer-of-dragons-register-of-estates-the-register/

Something for the weekend, sir? How many websites do I have? Come on, guess. Well done! You might be right… or maybe not. Honestly, I have no idea.

As the weeks slide into summer, a bi-annual recurring task pops up on my calendar to remind me it’s time to get out the digital pruners and reduce my online proliferation.

My calendar does that sort of thing. Other people’s calendar apps are full of meetings and birthdays, or weekly prompts to upload another blatant message of virtue on LinkedIn. If you use Calendly, you may notice that it now also works as a subliminal cheat sheet to take regular bathroom breaks.

The ease with which I can disparage point sites for one-time purposes tends to leave a trail of dead subdomains in my wake. They are always created in a rush for something that probably seemed very important at the time, then forgotten a week later. Every six months, I force myself to sweep up the debris. And once a year, I plan to condense the various email addresses I’ve accumulated over the past 12 months into aliases or delete them altogether: most were created for one-time login credentials anyway. , designed to be abandoned immediately after… something I always forget to do.

Considering the amount of valid inbound and outbound email that goes astray or speaks directly to recipients these days, I can even search for a more reliable host with a better WHOIS reputation. I find the simple process of changing domains quite stressful – did I save everything? Will messages be rejected? Are the servers really located in Europe or does the host just clone big boys in the US? – to continue to put it back. My calendar reminds me that it has been over a decade since I last did this. Wish me good luck.

Putting away my toys after play is boring, so I put some soothing music in the background. I read somewhere – maybe in one of those aforementioned LinkedIn arseguffs – that the right kind of background sounds will lengthen my powers of focus. Or extend my life. Or penis. I don’t remember exactly; hope this lengthens my memory retention.

Speaking of empty posts of tiny inspiration by cunning auto-sellers with hidden agendas, I read one this week on LinkedIn that proclaimed: “No one puts their job title, degrees or work history on their stone. tomb. ” That was followed by the usual harassment of being nice to yourself, of living your life, that sort of thing. “Walk through any cemetery and you will see ‘Beloved Mother’, ‘Loving Father’, ‘Wonderful Friend’ carved into the stones. You are more than your job! “

Is it correct? I occasionally enjoy a non-macabre cemetery getaway and can assure you that the cemeteries are full of tombstones that particularly refer to the deceased’s ex-profession. Author, painter, master baker, doctor, engineer, longtime reverend of this parish, etc. Fair enough, I have yet to see a grave marked “James Clitheroe, VP Paperclips and Self-Adhesive Stationery Items (Northern Europe)”, but referring to the work of the dear deceased is a pretty standard thing.

What would you prefer on your gravestone instead – a list of your life experiences outside of work? “RIP James Clitheroe, Collected The attack of the Titans figurines, Had trouble starting her car on cold mornings “or maybe” Here lies Susan Donim, Tough Aunt, Disturbing Cat Lady, Watched a lot of Netflix “?

This is Spike Milligan’s gravestone. Who you ask ? Well, read it and you will find out: “Writer, artist, musician, humanitarian, comedian.” Five job titles! This LinkedIn poster would be appalled.

Spike Milligan's gravestone in Winchelsea, Kent

Spike Milligan’s gravestone in St Thomas’ Cemetery at Winchelsea. He told us he was sick

Notice that Spike’s grave also has his famous motto: “I Told You I Was Sick.” Unfortunately, local authorities have deemed it unworthy to put jokes on gravestones for fear of accidentally making cemetery visitors smile. Spike’s family were forced to disguise the motto by having it engraved in smaller letters using an almost illegible typeface and, to be on the safe side, translating it into Gaelic: “Duirt me leat go raibh me breoite. “

His gravestone faces the local pub just across the road.

Hmm, my audio that elongates schlong doesn’t seem to be playing. Or to work, by the look of it. Music was supposed to be streamed over the internet through an app but – nothing. No surprises there, to be honest: there has been a surge of interest in new audio technologies over the past 18 months and although there may be a lot of startups in this field dreaming of becoming unicorns. , most will be donkeys.

I don’t mean that badly. There will also be plenty of thoroughbred and stallion racehorses in the mix, and at this point it’s probably best that I, uh, throw off the fantastic equine analogies. Let’s untie the stirrups and walk.

One particular area of ​​audio hardware technology that is seeing a recovery right now is in vibrating and vibrating devices that transmit detectable sound into your body through parts of your body that are not necessarily your ears. I haven’t seen much of it in several years, not since I visited an IoT exhibit where a rep forced me to listen to terrible music with headphones crashing into my joints. jaw under my temples. In principle, the concept has some value because it leaves your ears open. In practice, well… nothing prepares you for the experience of hearing Justin Bieber through your teeth.

A company called Flexound, for example, launched something he calls Augmented Audio which he says plays sound through your skin. I even read the story of former Rolls Royce engineers who developed a “smart” baby sleeping mat which plays white noise or heart vibrations to help little Lilibet make the most of her afternoon nap.

This shows how far we have come. It wasn’t that long ago that you could only achieve this with a dummy and an overdose of Calpol. I wonder if they are doing it for the grown-ups.

So where are my soothing sounds? I quit and relaunched the app, checked for updates, and restarted my handset. The app still plays stupid – barely music to my ears. Or the jaw. Or private.

I visit the app’s website for clues, only to find that the website is down for maintenance. To be precise, a wait page tells me that they are moving to new servers and the process will take two weeks. Eek, if it’s gonna take that long for a real business, maybe I’ll put off moving my own things and leave them where they are a little longer.

“Here lies Alistair Dabbs. Father, writer, trainer, incredible stunts with grapefruit, fear of domain transfers.”

I like this idea. ®

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Alistair Dabbs

Alistair Dabbs is a freelance tech enthusiast, juggling tech journalism, training and digital publishing. Its first port of call for music these days is Bandcamp. Besides its generally ethical stance towards royalty payments to artists, it is an exceptionally good source of Canadian atmosphere, Scandinavian metal and others that no one else likes. More than Auto-save is for wimps and @alidabbs.




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About BAC, Singapore News & Top Stories https://brainethics.org/2021/06/17/about-bac-singapore-news-top-stories/ https://brainethics.org/2021/06/17/about-bac-singapore-news-top-stories/#respond Thu, 17 Jun 2021 21:00:00 +0000 https://brainethics.org/2021/06/17/about-bac-singapore-news-top-stories/

The Bioethics Advisory Board (BAC) was established by the Cabinet to deal with ethical, legal and social issues arising from biomedical science research in Singapore.

It has 15 members from various backgrounds such as law, biomedical research, medicine, philosophy, sociology and education as well as representatives of religious groups and the media.

The committee focuses on three main areas: protecting the rights and well-being of individuals; public education and source of information on bioethical issues; and the identification of general principles to govern the ethical, legal and social implications of research in human biology.

KEY MILESTONES

december 2000

The BAC is established.

July 2002

Next, Deputy Prime Minister Tony Tan announces the government’s acceptance of the BAC’s recommendations on research and cloning of human stem cells.

july 2010

BAC organizes and hosts the 10th World Congress on Bioethics.

april 2012

BAC President Richard Magnus becomes the first Singaporean appointed to UNESCO’s International Bioethics Committee (IBC) for the 2012-2015 term.

November 2013

Singapore is elected member of the Intergovernmental Bioethics Committee (IGBC) of Unesco during the 37th session of the General Conference of Unesco for the period 2013-2017.

October 2017

Singapore is re-elected as a member of the IGBC for the 2018-2021 term and re-elected as rapporteur of the IGBC for the 2018-2019 term.

February 2020

Professor Lee Eng Hin, member of the BAC, is appointed member of the International Bioethics Committee for the 2020-2023 term. He succeeds Mr. Magnus as Singapore’s representative to Unesco.


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Male rats giving birth show biotechnology needs to be regulated https://brainethics.org/2021/06/16/male-rats-giving-birth-show-biotechnology-needs-to-be-regulated/ https://brainethics.org/2021/06/16/male-rats-giving-birth-show-biotechnology-needs-to-be-regulated/#respond Wed, 16 Jun 2021 21:37:01 +0000 https://brainethics.org/2021/06/16/male-rats-giving-birth-show-biotechnology-needs-to-be-regulated/

Biotechnology is being exploited to accelerate social-revolutionary policies and get through what was once immutable. moral limits. The last example occurred in China, where scientific ethics will die. Here’s the story: Two Shanghai-based researchers surgically tied male and female rats. They then uteri transplanted into male rats and made sure that the blood of the females nourished the organs now in the male bodies.

The male rats were then “impregnated” with IVF and embryo transfer, and some of the males became mothers. “For the first time, we have built a mammalian animal model of male pregnancy,” the researchers boasted in an article published by BioRXiv, an open access journal hosted by Cold Spring Harbor.

Why do that? Part of the impetus may have been to advance a deeply arduous goal of the transgender movement, which is to enable trans women – biological men who identify as women – to give birth.

Indeed, some in bioethics consider this perspective as a human right. For example, an article in the Journal of Medical Ethics at the University of Oxford stated that “there is a moral imperative to ensure equitable access to UTx. [uterine transplant]”for” genetically XY [transgender] women.”

Failure to guarantee these patients the full experience of female reproduction, argued bioethicists, “discriminates against genetically XY women as a social group.” In other words, medical science has the duty of social justice to overturn the transphobic realities of nature.

Genome modification

Transgender is not the only area in which Big Biotech is radically reviewing procreation and the family. Take the genetic engineering of the human germ line, which is the modification of the genome in such a way that it is passed down from generation to generation.

Two genetically modified babies have already been born, again in China. Yes, there has been an international outcry. But beware, the controversy was not so much because of what was done, but when.

You see, the deadly sin did not change the germ lines of the children. This has always been a goal of research into gene editing in human embryos, blessed, among others, by the influential National Academy of Sciences.

No, the real great wrong was to do the deed before the audience has been properly anesthetized with soothing assurances from bioethicists that the moral, social, and security implications of the technology have all been properly addressed. Indeed, George Daley, the dean of Harvard Medical School, argued following the announcement that scientists are expected to continue to engage in human germline engineering despite the fury.

Biotechnologists are also determined to create “three-parent embryos”. The process, a near-cloning technique, removes the nucleus from a woman’s egg, places it in another woman’s egg that has had the nucleus removed, and then fertilizes the genetically modified egg with sperm. Here is, three biological parents.

The purported goal of this extreme method of procreation is to enable women to bear biologically related children without transmitting mitochondrial disease. Fine. But you know the technique, once perfected, would not stop there.

At some point, polyamorous trios desiring to have children biologically related to all mates will also request access. Considering the way medicine is now being applied to facilitate lifestyles as well as cure illnesses – and given the enormous money to be made – who thinks IVF clinics would say no? And if they did, they would likely be prosecuted for discrimination.

The same could be said of the fortunes to be made in other areas of intensive biotechnology research. For example, scientists are working to create human eggs and sperm from skin cells.

What are some of the potential uses for these manufactured sperm and eggs?

  • Unlimited eggs for research into human cloning and possibly the birth of a cloned child.
  • Creating massive amounts of cloned embryos for use in embryo research or once the artificial uteri are online, “fetal breeding”, that is, creating fetuses as ” donors ”for organ transplant patients.
  • Radically restructure the formation of the family, for example, making sperm from the skin cells of a woman to use it to father a child by his wife.

Experiment on embryos

Sure: Big Biotech intends to experiment more and more on embryos – and, I believe, possibly on fetuses – far beyond what they have done so far. Indeed, a main ethical obstacle hindering this end has just been repealed by the International Society for Stem Cell Research (ISSCR).

Until now, biotechnologists who experimented with human embryos were supposed to follow the “14-day rule”, meaning that experimental embryos had to be destroyed after two weeks. The time limit was supposedly chosen because that’s when the neural system begins to form.

But the real The reason was that scientists had not yet developed the techniques to keep embryos outside a woman’s body longer than that. Thus, by accepting nix experiments which they could not yet perform, the ISCCR created an open field for research which could be accomplished.

This research has allowed scientists to keep embryos longer, so the 14-day rule is now out of date. The new plan has no time limit, but relies on scientists to get each other’s ethical clearance before performing experiments.

Excuse me for being disappointed. Biotechnologists recently used body parts of nascent human beings in horrific experiments, with the full ethical approval of their peers. An article published in the prestigious scientific journal Nature discussed the “full thickness human fetal skin” transplant – (literally) scalped and skinned dead babies from abortions performed between 18 and 20 weeks, as a “platform for studying human skin infections”. The photos of the “humanized rat models” in the report are not for the faint of heart. They represent the fetal scalps attached to rats still with human hair.

How are these experiences going? Blame us. We allow “scientists” to self-regulate in the hope that they will give us miraculous breakthroughs in return. But to truly serve society in a beneficial way, science requires humility and good ethics to accompany its quests.

Or, in other words, any powerful business – and nothing beats the life-changing potential of biotechnology-Requires rigorous checks and balances to stay on track.

Here’s the gist: Unless society begins the crucial process of deciding, through democratic processes and laws, what to allow or prevent both on the scientific benefit that we hope to obtain and the ethical horrors we are morally bound to prevent – the dystopian future prophesied in the Brave New World novel will come true.

Award-winning author Wesley J. Smith is president of the Center on Human Exceptionalism at the Discovery Institute.

The opinions expressed in this article are those of the author and do not necessarily reflect those of The Epoch Times.


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Harbor BioMed and Dana-Farber Cancer Institute Collaborate to Advance New Biotherapies for Cancer Treatment https://brainethics.org/2021/06/16/harbor-biomed-and-dana-farber-cancer-institute-collaborate-to-advance-new-biotherapies-for-cancer-treatment/ https://brainethics.org/2021/06/16/harbor-biomed-and-dana-farber-cancer-institute-collaborate-to-advance-new-biotherapies-for-cancer-treatment/#respond Wed, 16 Jun 2021 05:08:00 +0000 https://brainethics.org/2021/06/16/harbor-biomed-and-dana-farber-cancer-institute-collaborate-to-advance-new-biotherapies-for-cancer-treatment/

CAMBRIDGE, Mass. and ROTTERDAM, Netherlands and SUZHOU, China, June 15, 2021 / PRNewswire / – Harbor BioMed (HKEX: 02142) today announced that it has entered into a multi-year, multi-faceted research collaboration agreement with the Dana-Farber Cancer Institute to co-develop novel biotherapies in the treatment of cancer.

Scientists at Harbor BioMed and researchers at Dana-Farber will work together to develop new oncology drugs, including bispecific antibodies and CAR-T cell products. In recent years, both bispecific antibodies and CAR-T cell therapies are regarded as the next generation solutions in the field of tumor immunology. For their ability to engage two different targets, bispecific antibodies are expected to expand the therapeutic possibilities of monoclonal antibodies (mAbs), and CAR-T cell therapy is an innovative immunotherapy that uses specially modified T cells to redirect them to target cancer cells. .

This strategic collaboration will leverage Harbor BioMed’s Harbor Mice® transgenic platform with Dana-Farber’s expertise in CAR-T cell development and basic oncology research to generate novel biotherapies.

Harbor BioMed’s antibody technology platforms – Souris Harbor®, which is based on two proprietary transgenic mouse platforms, will be used to generate therapeutic human antibodies. The platforms have great potential to generate both conventional and next-generation biologics, such as bi- and multi-specific, CAR-T or VH domain derivatives that are fully human, matured by affinity with excellent solubility and developability.

“We are delighted to initiate this collaboration with Harbor BioMed. The complementary technology and expertise between Harbor and DFCI will dramatically shorten the time between a new discovery and the development of optimized antibodies and cell therapies for clinical translation, ”said Dr. Eric smith, Laboratory Principal investigator and director of translational research for immune effector cell therapies at the Dana-Farber Cancer Institute.

“Collaboration with the world-renowned Dana-Farber Cancer Institute demonstrates HBM’s commitment to developing new drugs and fostering innovative, accelerated research. I believe this collaboration will ultimately result in better treatments for cancer patients, ”said Jingsong Wang, founder, CEO of HBM.

About the Dana-Farber Cancer Institute

Dana-Farber Cancer Institute is a teaching hospital in Harvard Medical School. Dana-Farber is committed to providing cancer patients with the best possible care today, while advancing the treatments of tomorrow through intensive basic and clinical research. We are a leader in developing national cancer treatment guidelines and in improving the quality and effectiveness of cancer care. Our unique model of multidisciplinary, compassionate and collaborative care puts patients and their families at the center of everything we do. Our areas of expertise include breast cancer, skin cancer, gynecological cancers, lung cancer, stem cell transplants and cancer clinical trials.

About Harbor BioMed

Harbor BioMed (HKEX: 02142) is a global biopharmaceutical company engaged in the discovery, development and commercialization of novel therapeutic antibodies focused on oncology and immunology. The Company builds its solid portfolio and differentiated pipeline through internal R&D capabilities, collaborations with co-discovery and co-development partners and selected acquisitions.

Harbor Mice’s proprietary antibody technology platforms® generate fully human monoclonal antibodies in the two heavy chain and two light chain format (H2L2), as well as the heavy chain only format (HCAb). Based on anti-HCAb antibodies, HCAb-based immune cell activators (HBICE ™) are capable of producing tumor-killing effects not achievable by traditional combination therapies. Integrating Harbor Mice® with a unique B cell cloning platform, our antibody discovery engine is very unique and efficient for the development of next generation therapeutic antibodies.

For more information, please visit www.harbourbiomed.com

SOURCE Port BioMed

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Delta variant of coronavirus mutates to ‘Delta Plus’, why you don’t need to panic https://brainethics.org/2021/06/15/delta-variant-of-coronavirus-mutates-to-delta-plus-why-you-dont-need-to-panic/ https://brainethics.org/2021/06/15/delta-variant-of-coronavirus-mutates-to-delta-plus-why-you-dont-need-to-panic/#respond Tue, 15 Jun 2021 04:21:30 +0000 https://brainethics.org/2021/06/15/delta-variant-of-coronavirus-mutates-to-delta-plus-why-you-dont-need-to-panic/

India

oi-Deepika S

|

Update: Tuesday, June 15, 2021, 10:01 a.m. [IST]

New Delhi, June 15: The delta variant was the fourth addition to a list that also includes variants first identified in the UK, South Africa and Brazil, blamed for the disastrous second wave of coronavirus infections in India.

Representation image

The super infectious Delta variant (B.1.617.2) of SARS-CoV-2 mutated again to form the “Delta plus” or “AY.1” variant, raising fears that these viruses could evade the immune response.

However, health experts said there was no immediate cause for concern in India as its incidence in the country is still low. Scientists have suggested that two doses of the vaccine, putting on masks and implementing the appropriate Covid standards would help fight the virus.

Studies suggest that the Delta plus variant shows signs of resistance against monoclonal antibody cocktail treatment, which was recently cleared by the Central Drugs Standard Control Organization (CDSCO) in Inida.

What is the Delta Plus or AY.1 COVID-19 variant

The Covid B.1.617.2.1 variant also known as AY.1 characterized by the acquisition of the K417N mutation and the mutation is found in the SARS-COV-2 spike protein, which helps the virus enter and infecting human cells.

The Delta plus variant was present in six Indian genomes as of June 7. So far, 63 Delta genomes (B.1.617.2) with the new K417N mutation have been identified to date as part of the global science initiative GISAID.

The Delta plus variant is mainly found in Europe, not India

In fact, Delta Plus variants are mostly found in Europe, Asia, and America with the exception of India. The first sequence of this genome was discovered in Europe at the end of March of this year.

Delta plus discovered he escaped monoclonal antibody treatment

An important point to consider regarding K417N is the “evidence suggesting resistance to the monoclonal antibodies Casirivimab and Imdevimab”. Monoclonal antibodies, which were seen as a viable treatment for Covid-19, have been touted as a game-changer in the fight against the pandemic.

Monoclonal antibody (mAb or moAb) is an antibody made by cloning a single white blood cell. All subsequent antibodies derived in this way can be traced back to a single mother cell.

The researchers revealed that the use of mAb is the main innovative approach that could prevent and treat infected patients. Several researchers are focusing on the development of new treatments based on specific mAbs to inhibit and / or neutralize SARS-CoV-2 in COVID-19 patients.

Casirivimab and imdevimab are monoclonal antibodies specifically directed against the SARS-CoV-2 spike protein and designed to block the uptake and entry of the virus into human cells.

The transmissibility of the new variant is a crucial factor

Allaying fears, immunologist Vineeta Bal noted that while there may be some setback in the use of the commercial antibody cocktail due to the new variant, resistance to treatment is not an indication of ‘increased virulence or severity of a disease.

“The degree of transmissibility of this new variant will be a crucial factor in determining whether or not it spreads rapidly,” Bal, visiting professor at the Indian Institute of Science Education and Research, Pune, told PTI.

She also noted that the quality and quantity of neutralizing antibodies, responsible for cell defense against pathogens, generated in the individual infected with the new variant is unlikely to be affected due to the mutation.

“So, in people infected with the new variant, this may not be an issue worth worrying about,” she added.

Pulmonologist and medical researcher Anurag Agrawal agrees.

“At this time, there is no reason to be concerned about the new variant in India,” Agrawal, director of CSIR-IGIB, told PTI.

Plasma from vaccinated people should be tested

The scientist said that the blood plasma of many fully vaccinated individuals will need to be tested against this variant to determine if it exhibits a significant immune breakout. As the Delta variant continues to evolve and acquire new mutations, there is a lot of interest in understanding its evolution.

He said that SARS-CoV-2 has an almost constant rate of acquisition of genetic variants, and that each variant has acquired additional variants in a gradual manner.

“Understanding this continuing evolution is of great importance for mapping the evolutionary landscape of emerging variants. The virus has largely attempted to optimize transmission and immune evasion through the gradual acquisition of new mutations,” he said. -he adds.


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Legends of Tomorrow recap and spoilers: S6, E6, “Bishop’s Gambit” https://brainethics.org/2021/06/14/legends-of-tomorrow-recap-and-spoilers-s6-e6-bishops-gambit/ https://brainethics.org/2021/06/14/legends-of-tomorrow-recap-and-spoilers-s6-e6-bishops-gambit/#respond Mon, 14 Jun 2021 16:56:17 +0000 https://brainethics.org/2021/06/14/legends-of-tomorrow-recap-and-spoilers-s6-e6-bishops-gambit/

WARNING: The following contains spoilers for DC’s Legends of Tomorrow Season 6, Episode 6, “Bishop’s Gambit,” which aired Sunday on The CW.

“Bishop’s Gambit” picks up right where “The Satanist’s Apprentice” left off, Sara Lance finding out that Bishop is a clone. She learns that he’s different from Ava’s clones as there will only be one at a time, with a backup ready to go in case something happens. Bishop explains that he can easily clone himself or any other organic being because science in his day made cloning a simple process. Sara is disgusted with his actions, knowing that he could use his skills to do good, but Bishop thinks he’s doing the right thing by restarting the human race. He then mocks Sara, stating that no one is coming to save her. However, at this point, Mick Rory and Kayla finally arrive on Bishop’s planet, ready to bring Sara back.

Meanwhile, back at Constantine’s house, the moving team proves overwhelming for the former master of the dark arts. An ever-hopeful Ava manages to connect Gideon to an old television, hoping to find clues to Sara’s location. Gideon discovers an alien massacre in a psychiatric ward in 1956, and while Ava is relieved to have a lead, Gideon reveals that the alien was called “Sara Lance”. The team reunites and discusses a plan, with Astra suggesting they bring the alien back to Constantine to question it. Ava accepts and the team mails to 1956 and is surprised to meet Amelia Earhart. However, Spooner cannot get an alien reading from her, which makes the situation odd. Either way, they take her back to Constantine’s house and dress the place up to look like an asylum to try and get answers without provoking her into a murderous rage.

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Behrad and Spooner team up to talk to him, Behrad taking the good cop approach and Spooner becoming the bad cop. However, they get no response, as Amelia is taking antipsychotic medication, which puts her state of mind out of balance. Spooner, wishing to speed up the process, secretly puts caffeine pills into Amelia’s tea, which ends up working as Amelia reveals that she left her ship in New York. Nate and Ava assume it’s a pod, so they go back to 1956, only to find the Waverider. Ava was hoping that Rory would come back with Sara, but after not getting an answer, she returns to Constantine’s house and questions Amelia, demanding to know where Sara is. This ends up waking the alien inside Amelia, but when she goes to attack Ava, she is stopped by Behrad and Spooner, who overpower her with tranquilizing darts.

With Amelia’s alien form awakened, the team needs a new plan to extract information from her. John suggests a spell that can extract memories that a person is trying to hide, even from themselves. However, John is helpless after the events of the last episode, so he tries to hide this secret by suggesting that Astra cast the spell under the guise of practicing his magic. They bring Amelia to the Waverider and tie her up, hoping to use the ship’s defenses as a precaution if something goes wrong. Astra prepares and casts the spell, seeing images of Amelia’s true memories. She discovers that while Amelia was traveling the world, she was kidnapped by the same ray that took Sara and, after escaping, took refuge on Bishop’s planet. Astra also discovers that Sara has met Amelia, but her memories are clouded, making it difficult to read them. Ava asks Astra to pass, but this unlocks the full alien form, which escapes from the straps and attacks Spooner, who yells at the alien in his own tongue. John begins to stress over what he did to Astra as Zari walks in and questions him, knowing something is going on.

RELATED: The Flash: How Cisco Is Leaving (& How It Could Return)

This course of events horrifies Spooner as she believes she has the potential to transform into a horrific alien like Amelia did. As Behrad does his best to comfort her, Spooner’s ability to understand and speak the alien’s language worries him, mainly because his powers have grown stronger and more refined since joining the Legends. . Behrad helps Spooner by letting him know that as a Legend, the past and the future are not important; what’s important is the present moment and what a Legend does about it. This helps Spooner, who uses his newfound ability to speak to the alien. She learns that Amelia killed Sara, or at least believes she did. Amelia then attacks Spooner and is about to kill her before Ava arrives with the save. That’s when Spooner lets Ava know that Sara is dead, which breaks her heart.

Back on Bishop’s home planet, Kayla discovers that her ship does not have a power cell. They then notice a soldier near Kayla’s ship, so Mick goes looking for answers. He is shocked to find out that the Soldier is an Ava clone and decides to be apprehended along with Kayla, seeing this as an advantage. Unfortunately for Kayla, Amelia Earhart steals the ship, leaving her with no back-up plan. Meanwhile, Sara finds a camera in her hospital room and covers it. But just as she does, Gary comes out of the toilet and lets her know he found the power cells. Sara tells him to get to the ship while she finds her own way out playing with Bishop’s game. She manages to get Bishop to lower his defenses by agreeing to help her, which leads him to invite her to dinner to celebrate. Outside, Kayla finds the batteries and tries to find a way to steal one. Suddenly her ex-fiancé Gary stumbles towards the cells, trying to sneak past a soldier Ava. Kayla uses this as an opportunity and shouts loudly that there is an intruder. Ava’s soldiers find Gary and take him away, leaving the power cells unattended.

RELATED: Legends of Tomorrow: Nick Zano Breaks Down Nate’s Past, Present & Future

Bishop is then informed of Mick’s capture and is upset that someone has come to save her, believing that Sara has joined her side and no longer needs to be rescued. He decides to take care of Mick by lowering the barrier that protects humans from the planet’s atmosphere, hoping that this will kill Mick and any other intruders on the planet. Her assistant Ava protests that her clone sisters are also outside and would die if the barrier was lowered, but Bishop pushes her away, declaring that all Avas are replaceable. As the barrier begins to drop, the soldiers tie Mick to a tree and let him die. But a quick-witted Mick manages to get out and uses a breathing mask to save time. As Mick manages to escape, Gary walks into the facility with a soldier Ava. The Avas inside recognize him and believe he has killed again, but the soldier informs his sisters that he saved her. Gary then apologizes for eating D-Squad and tells them about his kind-hearted leader Ava. Back outside, Mick finds a dying Kayla on the floor with an electric battery, which is too heavy for him to carry alone. He gives Kayla his breathing mask and they share it, hoping to survive as long as it takes to get back to his ship. Upon arrival, however, they are bombarded by locals attempting to enter the ship. When the attacking fails, Mick and Kayla lock themselves into a pod to stay safe. This allows the duo to bond, and before long they connect.

Sara and Bishop start their dinner with champagne, happy to be on the same side. But Sara notices the storm outside, that’s when Bishop lets her know that Mick has come to save her but is most likely dead. Angry, Sara beats Bishop until he loses consciousness and drags him to a lab where she discovers his rescue body. Sara then denounces Bishop’s cloned lifestyle, believing wholeheartedly that every scar on her body, every death, every wound is a lesson in life. Bishop oddly mentions that he can’t see a single scar on his body, despite his many years as a vigilante and assassin. At this point, it becomes clear to the public that Sara Lance, the person they followed from her first step on the Queen’s Gambit until the moment she first met Bishop, is dead and that the one who is found in the lab is a clone.

DC’s Legends of Tomorrow stars Caity Lotz, Dominic Purcell, Nick Zano, Tala Ashe, Matt Ryan, Olivia Swann, Jes Macallan, Adam Tsekhman, Shayan Sobhian, Lisseth Chavez and Raffi Barsoumian. Season 6 airs Sundays at 8 p.m. ET / PT on The CW.

KEEP READING: Legends of Tomorrow’s Astra Breaks Down The Team’s First Animated Adventure

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